Acute changes of neurovascular coupling following cortical spreading depression in anesthetized rats

Ute Lindauer, Caroline Böttiger, Martina Füchtemeier, Plamena Stroh, Christoph Leithner, Georg Royl, Ulrich Dirnagl & Nikolas Offenhauser
Objective: Within the first hours after cortical spreading depression (CSD) moderate hypoperfusion with impaired vascular reactivity occurs. However, it is not investigated in detail, whether the observed alteration of cerebrovascular reactivity has any impact on neurovascular and neurometabolic coupling.[for full text, please go to the a.m. URL]