Ventricular hemorrhage causes necrosis of human astrocytes by a cytosolic Ca2+-overload and mitochondrial damage

Wolfram Scharbrodt, Yaser Abdallah, Mohammed Miqdad, Sascha A. Kasseckert, Marco Stein & Matthias F. Oertel
Objective: Ca2+ is a cofactor of many intracellular processes including apoptosis and necrosis. This study’s hypothesis was that bloody CSF from patients after intraventricular hemorrhage (IVH) may cause a Ca2+-rise which induces a mitochondrial dysfunction that results in necrosis [for full text, please go to the a.m. URL]