Somatically acquired and radical associated damage of mitochondrial DNA in osteoarthritis

J. Zwingmann, B. Setzer, M. Große Perdekamp, W. Schlickewei, N. P. Südkamp & U. Walker
Objective: Idiopathic osteoarthritis (OA) is a degenerative joint disease with age-associated cartilage breakdown. The mitochondrial theory of aging suggests that chronic production of reactive oxygen species (ROS) within aging mitochondria is associated with loss of cellular function. ROS may in turn[for full text, please go to the a.m. URL]