Apolipoprotein E inhibits osteoblast differentiation and function by suppression of canonical wnt/ß-catenin signaling

A. Niemeier, A. Goetz, S. Rukiye, W. Qiu, W. Ruether & J. Heeren
Objective: We have previously shown that apoE -/- mice display a high bone mass phenotype due to an increased bone formation rate. It remained unclear whether this phenotype was a secondary consequence of systemic influences onto osteoblasts or due to a cell autonomous effect of osteoblasts lacking[for full text, please go to the a.m. URL]