Influence of activating Ras-mutations on radioresistance mechanisms in epithelial cancer cells

Annette Affolter, Wolf J. Mann & Jürgen Brieger
Irradiation- stimulated signalling via the two pathways Raf-MEK-ERK and PI3K/Akt is known to be closely associated with a limited response to radiotherapy in HNSCC. In the present study, we have addressed the question whether the K-Ras mutation G12S causing constitutive activation of ERK and Akt[for full text, please go to the a.m. URL]