Protection of spiral ganglion cells in vivo after implantation of model electrodes coated with BDNF-producing cells

Athanasia Warnecke, Timo Stöver, Susanne Sasse, Gentiana I. Wenzel, Kirsten Wissel, Andrea Hoffmann & Thomas Lenarz
Long-term drug delivery to the inner ear may be achieved by functionalization of cochlear implant electrodes with cells providing neurotrophic factors to the spiral ganglion cells (SGC). In a previous study we demonstrated survival of NIH3T3/BDNF cells on model electrode surfaces, release of bioactive[for full text, please go to the a.m. URL]