The role of Cyclooxygensases, Vascular Endothelial Growth Factor and Survivin in the pathogenesis of chronic rhinosinusitis and analgetics intolerance

Kai Fruth, Chengjing Zhu, Eduard Schramek, Juergen Brieger & Wolf Juergen Mann
Background: The Cyclooxygenases (Cox) play a key role in arachidonic acid metabolism. An imbalance of leucotriens and prostaglandins is considered to be a major component in the pathogenesis of nasal polyps occurring in combination with analgetics intolerance. Recent findings suggest the involvement[for full text, please go to the a.m. URL]