Chromosomal instability predicts the progression of premalignant oral lesions

Rinske M.P.T. Hamers, Thijs M.A.W. Merkx, Bernd Kremer, Ernst-Jan M. Speel, Theke J.H. Siebers, Annick Haesevoets, Iris R. Zwijnenberg, Adri C. Voogd, Pieter J. Slootweg & Frans C.S. Ramaekers
Objective: A major dilemma in the management of patients with precursor lesions of the oral mucosa lies in deciding which lesions will progress into carcinoma. The aim of this study was to evaluate the value of chromosomal instability (CIN) detected by fluorescence in situ hybridization (FISH) for the[for full text, please go to the a.m. URL]