TNFα compromises the inner ear microcirculation in a sphingosine kinase 1/sphingosine-1-phosphate dependent manner – a novel mechanism for sudden hearing loss (SHL)

Elias Scherer, Jingli Yang, Karolina Ivanov, Christian David Diehl, Katrin Reimann, Philine Wangemann, Martin Canis, Sebastian Strieth, Julia Voigtlaender-Bolz & Steffen-Sebastian Bolz
This study establishes a link between inflammation and inner ear vascular dysfunction. Recovery of auditory function in sudden hearing loss (SHL) patients treated with a TNFα inhibitor were consistent with a vascular origin. We investigated the inner ear microcirculation using (1) an in vitro [for full text, please go to the a.m. URL]