Differences in the frameshift-regulating p1-site in treatment-naïve and PI-resistant HIV isolates

E. Knops, G. Théberge-Julien, R. Kaiser, D. Hoffmann, L. Brakier-Gingras & J. Verheyen
Objectives: The HIV replication cycle include a maturation step, in which the viral enzymes are cleaved from the Gag-Pol precursor built due to a frameshift event in p1. Two Gag cleavage-sites (CS) (p7/p1, p1/p6-gag), which were found to be important in PI-resistant HIV, and Pol CS (p7/TFP,[for full text, please go to the a.m. URL]