Macrophage TRAIL expression is IFN- β-dependent and mediates alveolar epithelial apoptosis and barrier dysfunction in influenza virus pneumonia

K. Högner, H. Janßen, S. Pleschka, J. Albrecht, F. Driever, W. Seeger, J. Lohmeyer & S. Herold
Introduction: Influenza virus (IV) pneumonia occasionally progresses to acute lung injury (ALI/ARDS). Although alveolar macrophages (AM) have been attributed a significant role in the host defense towards IV, they were shown to contribute to lung injury progression by release of pro-inflammatory[for full text, please go to the a.m. URL]