Frequencies of Hepatitis B surface antigen mutations in drug resistant Hepatitis B virus isolates

M. Neumann-Fraune, N. Sichtig, M. Obermeier, T. Berg, B. Beggel, D. Glebe, R. Kaiser & J. Verheyen
Background: Chronic HBV infection can cause liver-cirrhosis or hepatocellular carcinoma. Different antiviral therapy regimens are used to influence the disease progression. An obstacle regarding sustained suppression of viral replication are emerging drug-resistances. Due to overlapping reading-frames[for full text, please go to the a.m. URL]