“Dimerization inhibitors” of HIV-1 protease: from interface targeting peptides to triterpenes

H.J. Schramm & W. Schramm
The two identical subunits of HIV protease (PR) are connected by a β-sheet of four end segments. The terminal peptides disrupt the PR dimer into inactive subunits (“dimerization inhibitors”, DIs). Highly active DIs have been derived, e.g. Palmitoyl-YE(X) [X = Tyr, thyronine,[for full text, please go to the a.m. URL]