A novel real-time efflux assay reveals that selective serotonin reuptake inhibitors inhibit efflux of the near-infrared dye 1,2-dinaphthylamine in Escherichia coli strains overexpressing different RND pumps

J.A. Bohnert, S. Schuster, M. Szymaniak-Vits & W.V. Kern
Background: Multidrug resistance (MDR) is increasingly limiting treatment options in human and veterinary medicine and is often caused by MDR-efflux pumps. To combat MDR, pharmacological inhibition of efflux pumps has become an attractive approach. A variety of phenothiazines and, more recently, selective[for full text, please go to the a.m. URL]