IL-1 receptor antagonist exerts anti-apoptotic and barrier-protective effects towards alveolar epithelium in a murine model of LPS-induced acute lung injury

S. Herold, T. Shafiei Tabar, H. Janssen, W.A. Kuziel, W. Seeger, M. Steinmueller & J. Lohmeyer
Background: Acute lung injury (ALI) is a frequent complication of gram-negative pneumonia and is characterized by high alveolar levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and alveolar barrier dysfunction. However, the contribution of IL-1β to epithelial injury[for full text, please go to the a.m. URL]