Epistatis between the effects of sickle cell trait and a+-thalassaemia on the risk of malaria

B. Kreuels, S. Adjei, C. Ehmen & J. May
Objectives: Recently, antagonistic epistasis between the malaria-protective effects of sickle-cell-trait and a+-thalasaemia has been shown. It has been discussed that this genetic interaction might help to understand the global distribution of the sickle cell polymorphism. The aim of the study [for full text, please go to the a.m. URL]