Impact of the specific JNK inhibitor D-JNK-1on acute and chronic colitis in a DSS mouse model

Sabine Kersting, Christoph Hilgert, Volker Behrendt, Jonas Kersting, Monika Janot, Dominique Sülberg, Thomas Herdegen, Waldemar Uhl & Ansgar Chromik
Introduction: The c-Jun N-terminal kinase (JNK) is involved in maturation and activation of T cells and the synthesis of pro-inflammatory cytokines. Several studies demonstrated the relevance of the JNK pathway in inflammatory bowel diseases (IBD). Thus JNK inhibition may represent a potential therapy[for full text, please go to the a.m. URL]