Thymidylatsynthase and cyclin D1 protein expression in lymphnode negative colorectal cancer: role as prognostic factors?

Andrea Formentini
Introduction: Thymidylatsynthase is an enzyme for DNA-synthesis and the target for 5-fluorouracil whereas cyclin-D1 plays a critical role in the progression of cells through the G1 phase of the cell-cycle. There is evidence that expression of these markers may predict the outcome of patients with colorectal[for full text, please go to the a.m. URL]