CK1 delta promotes progression of SV40-induced in situ to invasive mammary carcinomas

Heidrun Hirner, Arnhild Grothey, Joachim Bischof, Wolfgang Deppert, Doris Henne-Bruns & Uwe Knippschild
Introduction: CK1δ phosphorylates key regulator proteins involved in cellular processes (e.g. proliferation, apoptosis) and modulates the activity of viral proteins, among them SV40 T-antigen. We generated a dominant negative mutant of CK1δ (mutCK1δ) with a highly reduced kinase activity,[for full text, please go to the a.m. URL]