A Gene Expression Signature for Chemoradiosensitivity of Colorectal Cancer Cells

Melanie Spitzner, Georg Emons, Frank Kramer, Jochen Gaedcke, Margret Rave-Fränk, Heinz Becker, Tim Beißbarth, B. Michael Ghadimi, Thomas Ried & Marian Grade
Introduction: The standard treatment of patients with locally advanced rectal cancers comprises preoperative 5-fluorouracil–based chemoradiotherapy followed by standardized surgery. However, the tumor response to multimodal treatment has varied greatly, ranging from complete resistance to complete[for full text, please go to the a.m. URL]