Tumor derived Foxp3 expression is one effective tumor immune evasion mechanism with prognostic significance in colorectal cancer

Martin Gasser, Martin Grimm, Mia Kim, Maria Lazariotou, Christoph-Thomas Germer & Ana Maria Waaga-Gasser
Introduction: Identification of CD4+CD25+ regulatory T cells (Treg) has been shown to play a role in maintaining immunologic tolerance. The transcription factor forkhead box P3 (Foxp3) has been identified as a key player in Treg function and is a definitive marker of CD4+CD25+ Treg.[for full text, please go to the a.m. URL]