Wnt/β-catenin signaling mediates resistance of colorectal cancer cells to radiation

Emil Kendziorra, Kerstin Ahlborn, Melanie Spitzner, Georg Emons, Margret Rave-Fränk, Jochen Gaedcke, Heinz Becker, Tobias Pukrop, B. Michael Ghadimi, Thomas Ried & Marian Grade
Introduction: The clinical response of locally advanced rectal cancers to preoperative chemoradiotherapy is very heterogeneous. To determine the molecular characteristics underlying this heterogeneous response, we recently used gene expression microarrays to profile a series of responsive and resistant[for full text, please go to the a.m. URL]