Specific activity of cyclin dependent kinase 1 as a novel predictor of recurrence risk in stage II colon cancer

Matthias Maak, Eliane Zeestraten, Masaki Shibayama, Tibor Schuster, Tomoko Matsushima, Satoshi Nakayama, Helmut Friess, Cornelis J. H. Van De Velde, Hideki Ishihara, Robert Rosenberg, Peter J.K. Kuppen & Klaus-Peter Janssen
Introduction: Altered cell cycle dynamics and check points are typical features of solid tumors, and cyclin dependent kinases (CDKs) play pivotal roles in these processes. Previously we have demonstrated that CDK-based analysis, composed of CDK1 and CDK2, is a useful prognostic marker for early breast[for full text, please go to the a.m. URL]