Invasion front-specific overexpression of ZEB2 is an independent prognostic marker in colorectal cancer and regulates tumor invasion in vitro

Christoph Kahlert
Introduction: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and dissemination. EMT occurs predominantly at the tumor edge where it is induced by cytokines, the extracellular matrix environment or hypoxia. In the tumor cell, it is further mediated by several transcription[for full text, please go to the a.m. URL]