CpG island methylator phenotype infers a poor prognosis in locally advanced rectal cancer

Peter Jo, Klaus Jung, Marian Grade, Lena-Cristin Conradi, Hendrik Andreas Wolff, Heinz Becker, Josef Rüschoff, Arndt Hartmann, Tim Beissbarth, Annegret Müller-Dornieden, Michael Ghadimi, Regine Schneider-Stock & Jochen Gaedcke
Introduction: Locally advanced rectal cancers are treated with preoperative radiochemotherapy (RT/CT). However, subsets of patients have no benefit from neoadjuvant treatment. Since epigenetic modifications, including DNA methylation, may influence response to neoadjuvant treatment we studied the[for full text, please go to the a.m. URL]