Inhibition of the epidermal growth factor receptor reverses ATP-binding cassette protein mediated multi-drug resistance in hepatocellular carcinoma

Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Daniel Schultze, Susanne Serba, Markus W. Büchler & Peter Schemmer
Introduction: Signalling through the epidermal growth factor receptor (EGFR) activated tyrosine kinase cascade and over-expression of multi-drug resistance mediating ATP-binding cassette proteins (ABC transport proteins) play an important role in the development of hepatocellular carcinoma (HCC). Recent[for full text, please go to the a.m. URL]