Targeting tumor stroma and angiogenesis using suicide-gene carrying mesenchymal stem cells results in reduced tumor growth in hepatocellular carcinoma

Hanno Nieß, Qi Bao, Bettina Schwarz, Karl-Walter Jauch, Peter Nelson & Christiane Bruns
Introduction: Mesenchymal stem cells (MSCs) are actively recruited to the stroma of some growing epithelial tumours and trans-differentiate into tumor-associated cells. MSC promote tumour growth and the formation of metastases in vivo by participating in angiogenesis and by expression of the chemotactic[for full text, please go to the a.m. URL]