A Smac Mimetic Blocks TRAIL-Induced Invasion and Metastasis of Cholangiocarcinoma Cells by Inhibition of NF-κB

Christian Dominik Fingas, Ali Canbay, Alphonse E. Sirica, Andreas Paul & Gregory J Gores
Introduction: Cholangiocarcinoma (CCA) remains a devastating disease with limited therapeutic options. CCA cells paradoxically express TRAIL, an apoptosis-inducing ligand which, failing to kill CCA cells, instead promotes their tumorigenicity, especially NF-κB-mediated metastasis. Smac mimetics[for full text, please go to the a.m. URL]