Antiproliferative Effect of Telmisartan via PPARγ-Activation in Human Colon Cancer Cells

Lucas Dong-Gun Lee, Benjamin Mafura, Sonja Dullat, Johannes Christian Lauscher, Heinz Joachim Buhr, Jörg-Peter Ritz & Jörn Gröne
Introduction: Telmisartan, an AT1-Receptor-Antagonist for essential hypertension therapy, also shows partial Peroxisom Proliferator Activated Receptor γ (PPARγ) activation in preadipocytes with metabolic effects. In tumor cells, PPARγ activation leads to apoptosis and cell cycle inhibition.[for full text, please go to the a.m. URL]