Tetrahydrobiopterin protects pancreatic grafts from ischemia-reperfuson-injury: Does the endothelial nitric oxide synthase play a role?

Benno Cardini, Gerald Brandacher, Martin Hermann, Katrin Watschinger, Rupert Oberhuber, Peter Obrist, Raimund Margreiter, Johann Pratschke, Ernst R. Werner & Manuel Maglione
Introduction: Ischemia-reperfusion-injury (IRI) following pancreas transplantation (PTX) is a major cause of graft pancreatitis. The essential cofactor of nitric oxide synthase (NOS) and potent antioxidant tetrahydrobiopterin (H4B) was shown to significantly attenuate IRI-induced graft pancreatitis.[for full text, please go to the a.m. URL]