Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition

Clemens Schafmayer, Stephan Buch, Henry Völzke, Marcus Seeger, Witigo Von Schönfels, Juan Francisco Miquel, Silvia Sookoian, Jan Egberts, Alexander Arlt, Carlos Pirola, Markus Lerch, Ulrich John, Andre Franke, Oliver Von Kampen, Mario Brosch, Michael Nothnagel, Wolfgang Kratzer, Bernhard Boehm, Dieter C. Bröring, Stephan Schreiber, Michael Krawczak & Jochen Hampe
Introduction: Genome-wide association studies have mapped loci that are associated with serum levels of bilirubin. Bilirubin is a major component of gallstones, so we investigated whether these variants predict gallstone bilirubin content and overall risk for gallstones. Materials and methods: Loci[for full text, please go to the a.m. URL]