Targeting EGF-receptor in malignant gliomas with double stranded RNA poly(I:C) and polyethylene glycol-linear polyethylenimine as a carrier molecule

V. Albrecht, J. Thorsteinsdottir, E. Wagner, J.C. Tonn, M. Ogris & C. Schichor
Objective: Glioblastoma multiforme (GBM) is characterized by an over-expression of the wtEGF receptor (EGFR) and its variant vIII (deltaEGFR), which is important for proliferation, invasion and angiogenesis of glial tumor cells. Targeted cellular delivery of proapoptotic, immune stimulatory double-stranded[for full text, please go to the a.m. URL]