Gene regulation by short-term and long-term hypoxia in glioblastoma stem cell lines

A. Kathagen, A. Schulte, H. Günther, H. Phillips, M. Westphal & K. Lamszus
Objective: Tumor stem cells (TSC) are believed to be responsible for continuous glioma growth and progression. As severe hypoxia in distinct regions of tumors is one major hallmark of glioblastomas and a well-known factor involved in maintaining the TSC phenotype in glioblastomas, these regions may [for full text, please go to the a.m. URL]