Local anti-epileptic therapy with valproate mini-pumps and gel in a mouse model of pharmacoresistant epilepsy

T.M. Freiman, D.M. Altenm├╝ller, C.A. Haas, T.J. Feuerstein & J. Zentner
Objective: In patients with pharmacoresistant epilepsy caused by an epileptogenic focus in an eloquent brain area, operative resection may result in severe neurological deficits. Therefore we have developed a novel experimental technique by implanting valproate-containing osmotic minipumps with a catheter[for full text, please go to the a.m. URL]