The role of sphingosine kinase isoforms and their receptors in growth of primary, secondary and recurrent glioblastoma

M. Kolodziej, N. Stiel, K. Quint, M. Ocker, H. Strik, L. Benes & C. Nimsky
Objective: Sphingosine 1-phosphate (S1P), a sphingolipid metabolite playing an important role in the regulation of cell survival, growth, migration and angiogenesis, acts both inside the cells and as an extracellular mediator through binding to five G protein-coupled receptors, S1P1-5. Sphingosine kinase[for full text, please go to the a.m. URL]