Unfavourable prognostic influence of IDH1 mutations in WHO Grade II astrocytomas turns into favourable predictive impact after malignant transformation

N. Thon, S. Eigenbrod, S. Kreth, J. Lutz, J.-C. Tonn, H. Kretzschmar, A. Peraud & F.-W. Kreth
Objective: The favourable impact of isocitrate dehydrogenases 1 (IDH1) mutations is well documented for malignant gliomas. Its influence on WHO grade II gliomas, however, remains unclear. Methods: IDH1 codon 132 pyrosequencing was performed in a mainly surgically treated series of 159 adult patients[for full text, please go to the a.m. URL]