Intratumoral variation of MGMT promoter methylation in glioblastoma – a regional quantitative analysis

L. Dörner, K. Hattermann, A. Nabavi, U. Malkus-Coskun, H.M. Mehdorn & J. Held-Feindt
Objective: Hypermethylation of the DNA repair gene O6-methylguanine DNA methyltranferase (MGMT) has been associated with an increased survival of patients with glioblastomas receiving standard chemotherapy with the alkylating agent temozolomide. In the latest chemotherapy trials, the MGMT promoter methylation[for full text, please go to the a.m. URL]