Inhibition of the EGFR/MAPK pathway in glioblastoma cell lines at different points of application – inhibition of EGFR's tyrosine kinase via gefitinib causes a depression of PTPIP51

M. Petri, J. Planz, U. Nestler, A. Stenzinger, A. Paradowska & M. Wimmer
Objective: Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an interaction partner of 14-3-3β, which correlates with the grade of malignancy in gliomas. PTPIP51 expression is described in various carcinomas. Its overexpression was shown to enhance apoptosis in HeLa cells. The EGFR[for full text, please go to the a.m. URL]