Wnt-inhibitor DKK1 (Dickkopf 1) expression is determined by intercellular crosstalk and hypoxia in malignant gliomas

K.T. Guo, P. Fu, J.C. Tonn & C. Schichor
Objective: Wnt signalling pathways regulate proliferation, motility and survival in a variety of human cell types. DKK1 (Dickkopf 1) is a secreted Wnt inhibitory factor. It is described as tumor suppressor gene in breast cancer and a pro-apoptotic factor in glioma cells. In this study, we demonstrate[for full text, please go to the a.m. URL]