Extracellular biologically active proteasome in cebrebrospinal fluid: a novel function for a well-known protein?

O.M. Müller, J. Wiedemann, T. Anlasik, J. Thomassen, S. Sixt & U. Sure
Objective: To prove the existence and biological function of the free extracellular proteasome in the cerebrospinal fluid (CSF). The proteasome’s substrate ubiquitin has been proven to be biologically active in CSF. We hypothesized that the proteasome can also be found in the CSF, as in the e.g.[for full text, please go to the a.m. URL]