Mossy fiber sprouting in hippocampi of patients with temporal lobe epilepsy creates an inhibitory neuronal feedback circuit

T.M. Freiman, C.A. Haas, M. Frotscher & J. Zentner
Objective: Temporal lobe epilepsy is characterized by sclerosis of the hippocampus (Ammon’s horn sclerosis) with a specific loss of neurons in the subregions CA1 and in the hilus. In contrast, excitatory granule cells survive, but show a reorganization of their axonal connections. Their axons,[for full text, please go to the a.m. URL]