Multidrug transporter-inhibition in temporal lobe epilepsy – a study in resected tissue from pharmacoresistant, chronic epilepsy patients

N. Sandow, S. Gabriel, T.N. Lehmann, P. Horn, P. Vajkoczy & U. Heinemann
Objective: 30% of epilepsies are pharmacoresistant. Temporal pole resection is often the only therapeutic option. Two concepts that may be responsible for pharmacoresistance in epilepsy are part of the current discussion: a) the target hypothesis favors changes in target conformation of antiepileptic[for full text, please go to the a.m. URL]