NO donor JS-K enhances cytotoxic effects of radiotherapy in U87 gliomas in vitro

N.K. Thiede, B. Baumer, N. Osterberg, S. Bette & A. Weyerbrock
Objective: The dismal prognosis of glioblastoma patients is largely caused by a high level of drug and radioresistance. The nitric oxide donor JS-K releases nitric oxide in GST-overexpressing tumor cells after enzymatic activation by glutathione-S-transferase (GST) resulting in growth inhibition, chemosensitization[for full text, please go to the a.m. URL]