Inhibition of glioblastoma growth in an orthotopic xenograft model by using an IGF-1 receptor antibody

T. Martens, H.S. Günther, M. Westphal & K. Lamszus
Objective: The Insulin-like growth factor (IGF) is known to play a major role in many human cancers. Overexpression of its receptor IGF-1 stimulates cell migration and proliferation in human gliomas in vitro. Thus the IGF-1 receptor is a potential target for anti-tumor therapies and this has been shown[for full text, please go to the a.m. URL]