Lesions of the entopeduncular nucleus in rats worsen the disruptive effects of the NMDA receptor antagonist MK 801 on sensorimotor gating

G. Lütjens, J.K. Krauss & K. Schwabe
Objective: Sensorimotor gating is disturbed in certain neuropsychiatric disorders with known or proposed abnormalities of basal ganglia function such as schizophrenia, obsessive compulsive disorder and Tourette's syndrome. Prepulse inhibition (PPI) of the acoustic startle reaction is an operational[for full text, please go to the a.m. URL]