Impact of an oxygen scavenger and NF-κB-inhibitor (amifostine) on acute ischemia-reperfusion injury of the lung in an in-vivo animal model

B. Danner, A. Emmert, Ph. Klumpen, J. Emmigholz, V. Didilis, R. Waldmann-Beushausen, C. Mühlfeld & F. Schöndube
Objective: Ischemia-reperfusion injury (IRI) is a common problem in cardiothoracic surgery. We hypothesized that amifostine reduces pulmonary edema (PE) formation and blood-air barrier damage as well as the activation of NF-ĸB in IRI of the lung. Methods: In male Wistar rats (n=69) a t[for full text, please go to the a.m. URL]