To "correct" or to "adjust" for heart rate changes in the evaluation of QT interval prolongation

Arne Ring & Robert Schall
The assessment of QT prolongation in thorough QT (TQT) trials according to ICH E14 [ref:1] is often based on a two-step approach [ref:2]: Determination of the heart rate correction (e.g. slope between log(QT) and log(RR)) based on the data of this trial; Estimation of the [for full text, please go to the a.m. URL]