Integrated Genome-Wide Pathway Association Analysis Using Parallel Computing

Christine Herold & Tim Becker
Pathway association analysis (PAA) tests for an excess of moderately significant SNPs in genes from a common pathway. Here, we present a Monte-Carlo simulation framework that allows to formulate the main ideas of existing PAA approaches (SNP ratio test, ALIGATOR and GenGen, Fisher combination test) [for full text, please go to the a.m. URL]