Adjustment for baseline values when outcome changes are of interest – a comparison of recommendations for randomized controlled trials and genetic association studies

André Scherag, Sonali Pechlivanis, Carolin Pütter, Susanne Moebus & Karl-Heinz Jöckel
Objective: In observational studies like cohort studies [ref:3] and more recently in genetic association studies [ref:6] it has been claimed that adjusting for baseline values leads to biased effect size estimates. However, in randomized controlled trials analysts are strongly encouraged[for full text, please go to the a.m. URL]