Is there a danger of “biocreep” with non-inferiority trials?

Primrose Beryl & Werner Vach
Introduction: Non-inferiority(NI) trials test a hypothesis that a new treatment is not inferior to standard treatment. Bio-creep basically refers to the cyclical phenomenon where a slightly inferior treatment becomes the active control for the next generation of NI trials which over time leads to degradation[for full text, please go to the a.m. URL]